While Dr. Kim was a visiting scientist in Berkeley, we collaborated to develop a hydrogel release system for exosomes. In this paper, exosomes derived from M2-macrophages (M2-Mφs), which contain putative key regulators driving Mφ polarization, were used as local microenvironmental cues to induce reprogramming of M1-Mφs toward M2-Mφs for effective wound management. As an injectable controlled release depot for exosomes, hydrolytically degradable poly(ethylene glycol) (PEG) hydrogels (Exogels) are designed and employed for encapsulating M2-Exos to maximize their therapeutic effects in cutaneous wound healing. The degradation time of the hydrogels is adjustable from 6 days or up to 27 days by controlling the crosslinking density and tightness. The localization of M2-Exos leads to a successful local transition from M1-Mφs to M2-Mφs within the lesion for more than 6 days, followed by enhanced therapeutic effects including rapid wound closure and increased healing quality in an animal model for cutaneous wound healing. Collectively, the hydrolytically degradable PEG hydrogel-based exosome delivery system may serve as a potential tool in regulating local polarization state of Mφs, which is crucial for tissue homeostasis and wound repair. Access the paper here.
Congratulations to former visiting scientist Sun Kim on the upcoming publication of our collaborative work on wound healing mediated by exosome release from hydrogels
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Lab News
- Congratulations to Arianna Avellan for winning the best poster award at the 46th Annual Adhesion Society Meeting!
- Congratulations to Katerina Malollari on her exit seminar!
- Paper on Structure-Property Relationships of a Supramolecular Polymer Prodrug Published in PNAS!
- Congratulations to Kelsey DeFrates on being named a Siebel Scholar!
- Congratulations to Sally, Peyman and Katerina on Their Graduation!
- New York Times article about the Glycera jaw paper published this week in Matter
- Congratulations to Katerina and Peyman on the publication of their coauthored paper in Matter
- Congratulations to Arianna Avellan for being awarded a GEM Fellowship!
- Congratulations to Cynthia Perez for passing her PhD qualifying exam!
- Congratulations to postdoc Subhajit Pal for being selected to attend the 71st Lindau Nobel Laureate Meeting!
Upcoming Talks by Group Members
“Novel Materials Inspired by Catecholamine Polymers Found in Nature”, to be presented by Prof. Messersmith at the Gordon Research Conference on Peptide Materials, Galveston, TX, January 2023.
"Injectable Dynamic Covalent Hydrogels of Bioderived Polysaccharides for Thermal Insulation During Cryoablation of Tumors", to be presented by Prof. Messersmith at the American Chemical Society Spring Meeting, Indianapolis, IN, March 2023.
“TBD”, to be presented by Prof. Messersmith at the Gordon Research Conference on Biomaterials and Biocompatibility, Holderness School, NH, July 2023.
Recent Talks by Group Members
“Supramolecular Polymers for Drug-Induced Regeneration”, presented by Prof. Messersmith at the Polymers in Medicine and Biology Conference, Napa, CA November 30, 2022.
“Design, Interfacial Mechanics and Applications of Mussel-Inspired Polymers”, presented by Prof. Messersmith at UC-Merced Materials Science and Engineering Department, Nov 7, 2022, Merced, CA.
“Bioinspired Catecholamine Polymers”, presented by Prof. Messersmith at the Gordon Research Conference on Multiscale Mechanochemistry and Mechanobiology, Ventura, CA, August 2022.
“Molecular and Bulk Mechanics of Multifunctional Catecholamine Polymer Coatings”, to be presented by Prof. Messersmith at CIMTEC 2022 - 9th Forum on New Materials, Perugia, Italy, June 25-29, 2022.
"Bioinspired Polymers For Drug-Induced Regeneration", to be presented by Prof. Messersmith at the Nature Inspires Creativity Engineers (NICE) Conference, Nice, France, June 20-23, 2022.
“Design, Interfacial Mechanics and Applications of Mussel-Inspired Polymers”, to be presented by Prof. Messersmith at the Materials Research Society Spring Meeting, May 9, 2022, Honolulu, HI.
“Mussel-Inspired Polymers: From Molecular Mechanics to Applications”, to be presented by Prof. Messersmith at the Pierce Seminar Series, Department of Civil and Environmental Engineering, MIT, April 6, 2022.
“Biologically Inspired Strategies for Interfacial Control in Polymer Coatings” presented by Prof. Messersmith at the Technical Seminar Program, PPG Aerospace, Burbank, CA, March 17, 2022.
“Stick It: Bio-Inspired Adhesives”, presented by Prof. Messersmith at The Square Root of STEM seminar series, Center for Excellence in Education, March 6, 2022, McLean, VA.
“Supramolecular Polymers for Tissue Regeneration”, presented by Prof. Messersmith at the Terasaki Institute at UCLA, September 29, 2021.
“Molecular mechanics and applications of bioinspired catecholamine materials”, presented by Prof. Messersmith at the Materials Research Society Spring Meeting, Seattle, WA, April 19-23, 2021.
“Metal-Catechol Interactions in Mussel adhesion and Mussel-Inspired Materials”, presented by Prof. Messersmith at the Department of Energy and the Environment, Japan Advanced Institute for Science and Technology, March 11, 2021.